منابع مشابه
Endothelium-Derived Hyperpolarizing Factor-Fact or Fiction?
The vascular endothelium releases a diffusible factor that hyperpolarizes and hence relaxes vascular smooth muscle cells predominantly through activation of Ca(2+)-dependent K(+) channels. In the coronary circulation, this endothelium-derived hyperpolarizing factor appears to be a cytochrome P(450)-derived arachidonic acid epoxide, the release of which may play a crucial role in the maintenance...
متن کاملEndothelium-Derived Hyperpolarizing Factor and Vascular Function
Endothelial function refers to a multitude of physiological processes that maintain healthy homeostasis of the vascular wall. Exposure of the endothelium to cardiac risk factors results in endothelial dysfunction and is associated with an alteration in the balance of vasoactive substances produced by endothelial cells. These include a reduction in nitric oxide (NO), an increase in generation of...
متن کاملHydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice.
The endothelium plays an important role in maintaining vascular homeostasis by synthesizing and releasing several endothelium-derived relaxing factors, such as prostacyclin, nitric oxide (NO), and the previously unidentified endothelium-derived hyperpolarizing factor (EDHF). In this study, we examined our hypothesis that hydrogen peroxide (H(2)O(2)) derived from endothelial NO synthase (eNOS) i...
متن کاملLatest evidence in endothelium-derived hyperpolarizing factor research.
Discovery of the Nature of Endothelium-Derived Hyperpolarizing Factor (EDHF) in Animals and Humans Endothelial cells play an essential role in the regulation of vascular structure and function. The endothelium elaborates and liberates 3 major vasodilator substances: prostacyclin (PGI2), nitric oxide (NO) and EDHF. The importance of PGI2 and NO has been widely recognized, and PGI2and NO-related ...
متن کاملFactors, fiction and endothelium-derived hyperpolarizing factor - EDH(F)
1. The principal mediators of vascular tone are neural, endothelial and physical stimuli that result in the initiation of dilator and constrictor responses to facilitate the control of blood pressure. Tw o primary vasodilatory stimuli produced by the endothelium are nitric oxide (NO) and prostaglandins. An additional endothelium dependent vasodilatory mechanism is characterized as the hyperpola...
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ژورنال
عنوان ژورنال: Circulation
سال: 2001
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.103.12.1702